Brain Imaging, Genomics and the Prevention of Alzheimer’s Disease

We have been using brain imaging techniques to detect and track the progression of Alzheimers’s disease (AD) in clinically affected patients and in cognitively normal carriers of a common AD susceptibility gene. In this presentation, I will briefly review our brain imaging studies and high-density genome-wide association studies of AD, I will suggest how these techniques could help accelerate the evaluation of promising disease-slowing and prevention therapies, and I will note some of the mathematical and computational challenges that need to be addressed to help fulfill the promise of brain imaging and genomics in these endeavors.

Eric Reiman, Banner Alzheimer's Institute

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